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Related Experiment Videos

Factor XIII in a clinical material.

U Hedner, P Henriksson, I M Nilsson

    Scandinavian Journal of Haematology
    |April 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Factor XIII (FSF) levels were normal in patients with renal, liver, or heart diseases, and deep venous thrombosis. Low FSF levels were observed in sepsis, trauma, and bleeding disorders, indicating a role in bleeding tendencies.

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    Area of Science:

    • Hematology
    • Clinical Biochemistry

    Background:

    • Factor XIII (FSF) is crucial for stabilizing fibrin clots.
    • Assessing FSF levels is important for understanding coagulation disorders.

    Purpose of the Study:

    • To determine Factor XIII (FSF) levels in patients with various diseases.
    • To investigate the correlation between FSF levels and bleeding tendencies.

    Main Methods:

    • Factor XIII (FSF) was quantified using the amine incorporation method.
    • 339 patients with diverse conditions were analyzed.

    Main Results:

    • Normal FSF levels were observed in renal disease, liver disease, deep venous thrombosis, and congenital cyanotic heart disease.
    • Low FSF levels were associated with sepsis, multiple fractures, burns, and gastrointestinal bleeding, often alongside abnormal fibrinolysis or disseminated coagulation.

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  • No correlation was found between FSF and fibrinogen or fibrin/fibrinogen degradation products (FDP).

    • Conclusions:

    • Low FSF levels may contribute to bleeding tendencies, particularly when other coagulation disturbances or increased fibrinolysis are present.
    • FSF levels are not consistently correlated with fibrinogen or FDP levels in these patient groups.