Altered p21(WAF1/CIP1) expression is associated with poor prognosis in extrahepatic bile duct carcinoma

¹Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Japan.

|May 9, 2000

Abstract:

This study was designed to determine the clinical implications of p21(WAF1/CIP1) expression and the relationship between p21(WAF1/CIP1) expression and p53 status in extrahepatic bile duct carcinoma (EBDC). Low p21(WAF1/CIP1) expression was immunohistochemically detected in 23 (67.6%) of 34 EBDCs, moderate in six (17.7%), and high in five (14.7%). Kaplan-Meier curves showed that low and high p21(WAF1/CIP1) expressions were significantly associated with shortened disease-free survival (low vs. moderate, P=0.02; high vs. moderate, P=0.01). There was no correlation between p21(WAF1/CIP1) and p53 expression. These findings suggest that altered p21(WAF1/CIP1) expression exerts an adverse influence on the prognosis of EBDC.

Related Experiment Videos

Altered p21(WAF1/CIP1) expression is associated with poor prognosis in extrahepatic bile duct carcinoma

Related Concept Videos

Bacteriology of endotracheal tube biofilms and antibiotic resistance: a systematic review.

Creating a community-based comprehensive intervention to improve asthma control in a low-income, low-resourced community.

Use of acellular dermal matrices in laryngotracheal and pharyngeal reconstruction: systematic review.

Tunable phonon-cavity coupling in graphene membranes.

Social prescribing through arts on prescription in a U.K. city: participants' perspectives (part 1).

Social prescribing through arts on prescription in a U.K. city: referrers' perspectives (part 2).

CRISPR-based diagnostics as a specificity layer for the early detection of pancreatic cancer.

Plasma cfDNA fragmentomics enables non-invasive detection and preoperative risk stratification of bladder cancer in a multicenter study.

KEAP1 loss-of-function suppresses immunogenic ferroptosis and limits PD-1 blockade efficacy through an NRF2-FSP1 pathway.

CD44-galectin-9 and TGF-β-Smad3 Pathways Form an Autocrine Loop which Facilitates Human Cancer Cells to Self-Regulate their Immune Evasion Machinery.

Modulation of Ferroptosis Bridges Radiotherapy and Immunotherapy to Improve Cancer Treatment Outcomes.

Therapeutic potential of colchicine-binding site inhibitors in breast cancer brain metastasis.

Construction and verification of a nomogram to predict the probability of venous thromboembolism in lung cancer patients.

Research on prognostic prediction of colorectal cancer based on multi-dimensional biomarker features and machine learning models.

A partial response to atezolizumab in alveolar soft part sarcoma with near-complete resolution of extensive pulmonary metastases: a case report.

Metabolites from blood and formalin-fixed, paraffin-embedded tissue from participants with low- and high-grade prostate cancer: a pilot study.

Increased HIF-2α and CD105 (endoglin) expression is associated with poor differentiation in pheochromocytomas and paragangliomas.

Case Report: Neuroendocrine-low POU2F3-positive small cell lung cancer presenting as a diagnostically unstable thoracic malignancy.

Related Experiment Videos

Altered p21(WAF1/CIP1) expression is associated with poor prognosis in extrahepatic bile duct carcinoma

Abstract:

Related Concept Videos

Related Articles