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Some observations on the effects produced in white mice following the injection of certain suspensions of corroding
British Journal of Experimental Pathology
|February 1, 1975
Abstract:
Strictly anaerobic and facultatively anaerobic strains of "corroding bacilli" failed to produce any pathological symptoms when injected into white mice and no viable organisms could be recovered after 7 days. However, when these same strains were coupled with certain other living bacteria or certain sterile bacterial extracts, lesions developed from which corroding bacilli could be isolated even after 21 days.
Insights
Corroding bacilli alone did not cause disease in mice. However, when combined with other bacteria or their extracts, these anaerobic bacteria induced lesions and persisted in mice.
Area of Science:
- Microbiology
- Pathogenesis
- Anaerobic bacteria
Background:
- Corroding bacilli are anaerobic bacteria implicated in periodontal disease.
- Their pathogenic potential in vivo has not been fully elucidated.
Purpose of the Study:
- To investigate the pathogenicity of strictly anaerobic and facultatively anaerobic "corroding bacilli" strains.
- To determine if co-infection with other bacteria or bacterial products enhances pathogenicity.
Main Methods:
- Injection of specific bacterial strains into white mice.
- Co-administration of bacterial strains with other living bacteria or sterile bacterial extracts.
- Monitoring for pathological symptoms and bacterial recovery over time.
Main Results:
- Injected "corroding bacilli" strains did not induce pathological symptoms or survive beyond 7 days in mice.
- Co-infection with other bacteria or bacterial extracts led to lesion development.
- Corroding bacilli were recoverable from lesions for up to 21 days post-infection in co-infected mice.
Conclusions:
- "Corroding bacilli" require synergistic interactions with other microbial factors to establish infection and cause disease.
- These findings suggest a polymicrobial etiology for diseases associated with "corroding bacilli".