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Transfer factor I: methods of therapy.

A S Levin, L E Spitler, H H Fudenberg

    Birth Defects Original Article Series
    |January 1, 1975
    PubMed
    Summary
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    Transfer factor therapy can induce cell-mediated immunity in about 50% of patients with immunodeficiency disorders. It may also enhance chemotherapy and potentially offer an alternative to bone marrow transplants for certain conditions.

    Area of Science:

    • Immunology
    • Cellular Immunity
    • Immunotherapy

    Background:

    • Transfer factor, discovered in 1955, has been utilized therapeutically since 1969.
    • Its application spans disorders of cellular immunity, infectious diseases, and malignancies.
    • This report details extensive clinical experience with transfer factor therapy.

    Purpose of the Study:

    • To describe the experience and efficacy of transfer factor therapy.
    • To outline patient selection, therapeutic procedures, and monitoring protocols.
    • To evaluate transfer factor's role in severe combined dual system deficiency disorder.

    Main Methods:

    • Review of clinical cases and therapeutic outcomes.
    • Detailed description of transfer factor administration and efficacy monitoring.

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  • Assessment of adverse effects and synergistic potential with other treatments.

    • Main Results:

    • Transfer factor therapy induced clinically acceptable cell-mediated immunity in approximately 50% of patients with various immunodeficiency disorders.
    • Transfer factor demonstrated utility as an adjunct to chemotherapy.
    • Potential synergistic effects with fetal thymocytes were observed, suggesting an alternative to bone marrow transplantation.

    Conclusions:

    • Transfer factor therapy is effective in a subset of patients with immunodeficiencies.
    • It shows promise as an adjunct to chemotherapy and in combination with fetal thymocytes.
    • Further research may establish transfer factor as a viable alternative to bone marrow transplantation for specific severe immunodeficiencies.