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Allosteric drugs: thinking outside the active-site box
1Harvard Institute of Chemistry and Cell Biology, Boston, MA 02115-5731, USA. brian_dedecker@hms.harvard.edu
Chemistry & Biology
|May 10, 2000
Abstract:
Recently, a class of small molecules that thermally stabilize the tumor suppressor p53 was selected from a small-molecule library. This, and other recent work, demonstrates the feasibility of taking a lead from nature and selecting new classes of drugs that function by allosteric mechanisms.