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BgK anemone toxin inhibits outward K(+) currents in snail neurons
A Garateix1, R Vega, E Salceda
1Departamento de Bioactivos y Productos Naturales Marinos, Instituto de Oceanología, Ministerio de Ciencia, Tecnología y Medio Ambiente, La Habana, Cuba.
Brain Research
|May 10, 2000
Abstract:
We studied the effects of BgK toxin on outward K(+) currents in isolated neurons of the snail Helix aspersa, using the whole cell patch clamp technique. BgK partially and reversibly blocked K(+) currents in the 1 pM to 100 nM concentration range (n=53). The dose-response curve for BgK current inhibition had a maximum blocking effect at 100 nM. Our results indicate that BgK is a potent, apparently non-selective, K(+) channel blocker in molluscan neurons.