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Related Experiment Videos

The mismatch negativity during natural sleep: intensity deviants.

D H Loewy1, K B Campbell, D R de Lugt

  • 1Department of Psychology, University of Ottawa, Ottawa, Canada. loewy@stanford.edu

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|May 10, 2000
PubMed
Summary

Auditory event-related potentials (ERPs) reveal that the mismatch negativity (MMN) response to sound intensity changes is significantly reduced during REM sleep. This suggests altered auditory processing during this sleep stage.

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Area of Science:

  • Neuroscience
  • Sleep Science
  • Auditory Neuroscience

Background:

  • Auditory event-related potentials (ERPs) are crucial for understanding auditory processing.
  • The mismatch negativity (MMN) is a specific ERP component reflecting automatic detection of auditory change.
  • Investigating MMN during sleep provides insights into auditory perception and cognitive function during different sleep stages.

Purpose of the Study:

  • To investigate the presence and characteristics of auditory mismatch negativity (MMN) to intensity changes during wakefulness, stage 2 sleep, and REM sleep.
  • To compare MMN responses elicited by intensity increments and decrements across different states of consciousness.

Main Methods:

  • Auditory event-related potentials (ERPs) were recorded from 7 subjects during a single night in a laboratory setting.

Related Experiment Videos

  • An 'oddball' paradigm was used, presenting frequent 70 dB tones ('standards') with infrequent 80 dB intensity increment deviants and 60 dB intensity decrement deviants.
  • Stimuli were presented every 600 ms while subjects were awake but inattentive, and during stages 2 and REM sleep.

    • Main Results:

    • During wakefulness, intensity increments elicited a fronto-central negativity (N1-MMN and N2b components).
    • In REM sleep, increment deviants showed a delayed, albeit significant, negativity, not considered a typical MMN.
    • Decrement deviants elicited a small, non-significant MMN-like wave in wakefulness and REM sleep, and MMN was absent in stage 2 sleep.

    Conclusions:

    • The mismatch negativity (MMN) response to auditory intensity changes is significantly attenuated and delayed during REM sleep compared to wakefulness.
    • Auditory change detection mechanisms, as reflected by MMN, appear to be impaired during REM sleep.
    • Further research is needed to clarify the nature of the late negativity observed in REM sleep and its relation to auditory processing.