Related Experiment Videos
Resting metabolic rate, body composition, and serum leptin concentrations in a free-living elderly population
M Neuhäuser-Berthold1, B M Herbert, P M Lührmann
1Institute of Nutritional Sciences, Justus-Liebig-University, Giessen, Germany. Monika.Neuhaeuser-Berthold@ernaehrung.uni-giessen.de
Objective:
The present study investigated the relationship between serum leptin concentrations and resting metabolic rate (RMR) in a large study group of elderly individuals with special consideration of body composition and body fat distribution as possible confounders.
Design And Methods:
The subjects were 122 women (age: 69+/-6 years, body mass index (BMI): 26.3+/-3.6 kg/m(2)) and 82 men (age: 69+/-5 years, BMI: 26.0+/-2.6 kg/m(2)). RMR was measured by indirect calorimetry and body composition by the bioelectrical impedance method. Serum leptin levels were determined by radioimmunoassay.
Results:
There was a strong correlation between fat mass (FM) and serum leptin levels in both sexes. An age-related decline in leptin levels adjusted for FM was observed only in the women. After adjustment of RMR for both fat-free mass (FFM) and FM, leptin levels were not associated with RMR. In stepwise multiple regression analysis, FFM was the main predictor of RMR, explaining 35.8% and 47.6% of the variance of RMR in men and women respectively. FM did not explain variance in RMR in men, but accounted for 2.6% of the variance in RMR in women. Waist-hip-ratio and age influenced RMR only in males, explaining 5.7% and 4.0% of the variance in RMR respectively.
Conclusion:
Leptin is not a significant predictor of RMR in the elderly, but body composition and distribution of body fat are significantly associated with RMR.