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The synthesis of chiral cyanohydrins by oxynitrilases
H Griengl1, H Schwab, M Fechter
1Institute of Organic Chemistry, Technical University Graz, SFB Biocatalysis of the Austrian Science Fund, Stremayrgasse 16, A-8010 Graz, Austria. griengl@orgc.tu-graz.ac.at
Trends in Biotechnology
|May 10, 2000
Abstract:
Enantiomerically pure cyanohydrins are important synthetic intermediates for pharmaceuticals and agrochemicals. They are produced by enzyme-catalysed synthesis using oxynitrilases. Sufficient quantities of enzyme are available via cheap natural sources and there have been recent advances in overexpression production of cyanohydrins on an industrial scale.