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Decreasing incidence of CNS AIDS-defining events associated with antiretroviral therapy
A d'Arminio Monforte1, P G Duca, L Vago
1Institute of Infectious and Tropical Diseases, University of Milan, Italy. a-darm1@mailserver.unimi.it
Neurology
|May 10, 2000
Abstract:
The authors enrolled 1,029 patients with CD4 counts = 200/microL and no CNS AIDS-defining events (CNS-AIDS) between January 1993 and December 1998. The primary end point was the first appearance of CNS-AIDS. Three different periods and different antiretroviral regimens were considered. During the median follow-up of 329 days, 144 patients (9.5%) developed CNS-AIDS. The independent predictors were CD4 counts and therapy. All regimens decreased the risk of CNS-AIDS. Highly active antiretroviral therapy led to a 95% risk reduction in comparison with untreated patients.