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Related Concept Videos

Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

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Related Experiment Video

Updated: Jul 5, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

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The distribution of polymorphic traits in atopic asthmatic patients.

K Mano, S Harada, H Miyahara

    Acta Allergologica
    |July 1, 1975
    PubMed
    Summary

    This study found no significant genetic associations between most plasma protein and red cell enzyme polymorphic traits and atopic asthma. However, the alpha1-antitrypsin (Pi) system showed some differences in atopic patients compared to normal groups.

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    Published on: April 16, 2019

    Area of Science:

    • Immunogenetics
    • Clinical Medicine
    • Biochemistry

    Background:

    • Atopic asthma is a complex condition with potential genetic underpinnings.
    • Polymorphic variations in plasma proteins and red cell enzymes are common in human populations.
    • Understanding genetic associations can aid in understanding disease etiology.

    Purpose of the Study:

    • To investigate the phenotypic distribution and gene frequencies of various plasma protein and red cell enzyme systems in atopic asthmatic patients.
    • To compare these genetic profiles with those of normal control groups.
    • To identify potential genetic markers associated with atopic asthma.

    Main Methods:

    • Analysis of phenotypic distribution and gene frequencies for haptoglobin (Hp), transferrin (Tf), group specific component (Gc), cholinesterase (Cho E2), and alpha1-antitrypsin (Pi) in plasma.
    • Analysis of phosphoglucomutase (PGM), 6-phosphogluconate dehydrogenase (6-PGD), esterase D (Es D), phosphohexose isomerase (PHI), adenosine deaminase (ADA), and acid phosphatase (AcP) in red cells.
    • Comparison of gene frequencies between 127 atopic asthmatic patients and normal control groups.

    Main Results:

    • The phenotypic distribution of the alpha1-antitrypsin (Pi) system differed between atopic asthmatic patients and the normal group.
    • No significant differences were observed in the gene frequencies of other studied protein systems (Hp, Tf, Gc, Cho E2) or enzyme systems (PGM, 6-PGD, Es D, PHI, ADA, AcP) between the two groups.
    • The findings suggest a potential, though not definitive, link between the Pi system and atopic asthma.

    Conclusions:

    • Except for the alpha1-antitrypsin (Pi) system, no strong association was found between the studied polymorphic traits and atopic asthma.
    • Further research is warranted to explore the role of the Pi system in the pathogenesis of atopic asthma.
    • The majority of common polymorphic genetic markers do not appear to be significantly associated with atopic asthma in this cohort.