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[Drug resistance and proticinogenic types of Proteus mirabilis isolated from urinary tract infections]

L Szymaniak1, I Aleksandrowicz, S Giedrys-Kalemba

  • 1Katedra i Zakład Mikrobiologii i Immunologii Pomorskiej, Akademii Medycznej w Szczecinie.

Medycyna Doswiadczalna I Mikrobiologia
|May 10, 2000
PubMed

Insights

This study examined 88 Proteus mirabilis strains from urinary tract infections, finding that most ESBL producers were more antibiotic-resistant. Proticin typing revealed distinct patterns between ESBL-positive and ESBL-negative strains.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Clinical Research

Background:

  • Proteus mirabilis is a common cause of hospital-acquired urinary tract infections (UTIs).
  • Antibiotic resistance, particularly extended-spectrum beta-lactamase (ESBL) production, is a growing concern in managing UTIs.
  • Understanding strain characteristics like proticin susceptibility can aid in epidemiological tracking and treatment strategies.

Purpose of the Study:

  • To assess antibiotic susceptibility and ESBL production in Proteus mirabilis isolates from hospitalized UTI patients.
  • To investigate the proticin production and susceptibility patterns of these isolates.
  • To correlate ESBL production with antibiotic resistance and proticin types.

Main Methods:

  • Antibiotic susceptibility testing using the standard disc diffusion method (NCCLS guidelines).
  • Detection of ESBL production.
  • Proticin typing utilizing a standard strain set from the B. W. Senior collection.

Main Results:

  • 59% of the 88 Proteus mirabilis isolates were identified as ESBL producers.
  • ESBL-producing strains exhibited significantly higher resistance to antibiotics compared to ESBL-negative strains.
  • Distinct predominant proticin patterns were observed: P1,2(6)/SO (23%) and P1,2/SO (13.5%) in ESBL-positive strains, and P6/SO (16.6%), P1,2/SO (13.8%), and P3,6/SO (13.8%) in ESBL-negative strains.

Conclusions:

  • ESBL production in Proteus mirabilis is associated with increased antibiotic resistance in UTI patients.
  • Proticin typing reveals differential patterns between ESBL-producing and non-producing strains.
  • These findings contribute to understanding the epidemiology and characteristics of Proteus mirabilis in clinical settings.

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