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Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
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Helicobacter pylori infection in children with insulin dependent diabetes mellitus

D Arslan1, M Kendirci, S Kurtoglu

  • 1Department of Pediatrics, Erciyes University, Faculty of Medicine, Kayseri, Turkey. duranarslan@yahoo.com

Journal of Pediatric Endocrinology & Metabolism : JPEM
|May 10, 2000
PubMed

Insights

Helicobacter pylori (HP) infection is more common in children with insulin-dependent diabetes mellitus (IDDM). The duration of diabetes, not gastric emptying, correlated with HP status in these children.

Area of Science:

  • Pediatric Endocrinology
  • Infectious Diseases
  • Gastroenterology

Background:

  • Insulin-dependent diabetes mellitus (IDDM) is a chronic condition in children.
  • Helicobacter pylori (HP) is a common bacterial infection affecting the stomach.
  • The relationship between HP infection and IDDM in pediatric populations requires further investigation.

Purpose of the Study:

  • To determine the seroprevalence of Helicobacter pylori (HP) in children diagnosed with insulin-dependent diabetes mellitus (IDDM).
  • To compare HP seroprevalence between diabetic children and healthy controls.
  • To identify potential risk factors associated with HP infection in diabetic children.

Main Methods:

  • A serological test (ELISA) for anti-HP IgG antibodies was conducted.
  • The study included 88 children with IDDM and 42 healthy children as controls.
  • Diabetic children were analyzed based on HP status, comparing age, gender, diabetes duration, glycemic control (HbA1c), and gastric emptying time.

Main Results:

  • The seroprevalence of anti-HP IgG was significantly higher in diabetic children (55.6%) compared to healthy controls (30.9%) (p<0.01).
  • Among diabetic children, the duration of diabetes was the only factor that showed a significant correlation with HP status.
  • No significant relationship was found between HP status and gastric emptying time in the diabetic cohort.

Conclusions:

  • Children with IDDM exhibit a higher seroprevalence of Helicobacter pylori infection compared to their healthy peers.
  • The duration of insulin-dependent diabetes mellitus is a significant correlating factor for HP status in affected children.
  • Gastric emptying time does not appear to be influenced by or associated with HP status in children with IDDM.

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