Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Interconversion between dehydro-L-ascorbic acid and L-ascorbic acid.

Y Nishikawa¹, T Kurata

¹Institute of Environmental Science for Human Life, Ochanomizu University, Tokyo, Japan.

Bioscience, Biotechnology, and Biochemistry

|May 10, 2000

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Impact of the Lung Immune Prognostic Index in non-small-cell lung cancer patients with PD-L1-low/negative tumors receiving chemoimmunotherapy: a real-world multicenter retrospective study.

ESMO open·2025

Same author

Pemetrexed plus platinum with or without pembrolizumab in patients with previously untreated metastatic nonsquamous NSCLC: protocol-specified final analysis from KEYNOTE-189.

Annals of oncology : official journal of the European Society for Medical Oncology·2021

Same author

Monitoring of somatic mutations in circulating cell-free DNA by digital PCR and next-generation sequencing during afatinib treatment in patients with lung adenocarcinoma positive for EGFR activating mutations.

Annals of oncology : official journal of the European Society for Medical Oncology·2017

Same author

Viral load and ganciclovir (GCV) concentration in cerebrospinal fluid of patients successfully treated with GCV or valGCV for human herpesvirus 6 encephalitis/myelitis following umbilical cord blood transplantation.

Transplant infectious disease : an official journal of the Transplantation Society·2016

Same author

Autoxidation Reaction Mechanism for l-Ascorbic Acid in Methanol without Metal Ion Catalysis.

Bioscience, biotechnology, and biochemistry·2016

Same author

Possible Formation of Dehydro-L-ascorbic Acid from 2,3-Diketo-L-gulonic Acid in an Aqueous Solution.

Bioscience, biotechnology, and biochemistry·2016

Erythorbic acid (EA) can reduce dehydro-L-ascorbic acid (DAA) under neutral conditions, suggesting a potential in vivo interconversion between L-ascorbic acid (AA) and DAA, particularly in biological tissues.

Area of Science:

Biochemistry
Organic Chemistry

Background:

L-Ascorbic acid (AA) is a vital biological electron donor.
Erythorbic acid (EA), an epimer of AA, shares similar chemical properties.

Purpose of the Study:

To investigate the redox reactions between AA, EA, and their dehydro forms.
To explore the potential in vivo interconversion of AA and dehydro-L-ascorbic acid (DAA).

Main Methods:

1H-NMR spectroscopy to analyze redox reactions.
Radioluminography to confirm interconversion at low concentrations and neutral pH.

Main Results:

EA reduced dehydro-L-ascorbic acid (DAA) under neutral, but not acidic, conditions.
L-Ascorbic acid (AA) reduced dehydroerythorbic acid (DEA) under similar neutral conditions.

Related Experiment Videos

Interconversion between DAA and AA was confirmed in vitro at physiological concentrations and neutral pH.

Conclusions:

The study demonstrates a novel redox interaction between EA and DAA.
Results suggest that the interconversion between AA and DAA may occur in vivo, particularly in biological tissues like the liver.