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Clinical study on Alternaria spores sensitization
A C Negrini1, D Berra, P Campi
1Servicio de Alergología, Ospedale S. Martino, Génova, Italia.
Background:
sensitization to fungi spores is often associated with sensitization to other allergens and so it is difficult to estabilish the exact cause of illness.
Objective:
the aim of the study was to evaluate a group of patients monosensitized to Alternaria and to establish the prevalence, periodicity and clinical profile of this kind of sensitization.
Methods:
37 subjects who were monosensitized to Alternaria (prick-test positive), according to a previous epidemiological study were evaluated. Clinical symptoms and the period of their occurrence were taken into consideration as well as immunological parameters (RAST).
Results:
20 patients (over 50%) included in the study proved to be affected by asthma associated with other allergic symptoms and 22 patients (60%) presented perennial symptoms. The RAST carried out on 34 monosensitized subjects proved positive in 11 and negative in 23.
Conclusions:
Alternaria sensitization is characterized by a perennial periodicity with severe respiratory symptoms (asthma) which occur primarily in children. Prick test is preferable to and more reliable than RAST as a diagnostic test.
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