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Related Experiment Videos

[Solar urticaria: pre-PUVA UVA desensitization].

M Pont1, E Delaporte, A Bonnevalle

  • 1Clinique Dermatologique, Hôpital Claude-Huriez, CHRU, 59037 Lille Cedex.

Annales De Dermatologie Et De Venereologie
|May 11, 2000
PubMed
Summary
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Solar urticaria, a difficult-to-treat sun allergy, can be effectively managed with PUVA therapy after UVA desensitization when antihistamines fail. This approach helps patients tolerate sun exposure better.

Area of Science:

  • Dermatology
  • Photomedicine
  • Allergy

Background:

  • Solar urticaria is a rare condition causing wheals after sun exposure, often resistant to standard treatments.
  • Symptoms include itchy, red welts appearing minutes after UV radiation and resolving hours later.

Observation:

  • A 22-year-old male patient experienced severe solar urticaria unresponsive to antihistamines.
  • Initial PUVA (psoralen plus UVA) therapy triggered a systemic reaction, necessitating a modified approach.

Findings:

  • Phototesting revealed a low minimal urticarial dose for UVA (0.4 J/cm²).
  • A gradual UVA desensitization protocol over 9 days enabled successful PUVA therapy initiation.
  • This slow-increment PUVA approach induced tolerance to sun exposure.

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Implications:

  • Solar urticaria can significantly impair daily life, especially severe, treatment-resistant cases.
  • PUVA therapy, preceded by UVA desensitization, offers a viable treatment for antihistamine-refractory solar urticaria.
  • This method provides longer-lasting protection than UVA exposure alone, with weekly maintenance sessions possible.