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Updated: Jul 29, 2026

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
Published on: March 27, 2018
Long-term survival following coronary bypass surgery in patients with significant impairment of left ventricular
Insights
Coronary artery bypass grafting can significantly improve angina symptoms and long-term survival for patients with impaired left ventricular function. This procedure is not contraindicated by poor ventricular function.
Area of Science:
- Cardiology
- Cardiac Surgery
Background:
- Patients with severe angina and impaired left ventricular function often face poor long-term prognoses.
- The role of coronary revascularization in this high-risk group remains a critical question in cardiac surgery.
Purpose of the Study:
- To evaluate the impact of coronary artery bypass grafting (CABG) on long-term survival and symptom relief in patients with severe angina and hypokinetic left ventricles.
Main Methods:
- Analysis of 62 consecutive patients with severe angina and impaired left ventricular function (LVED >= 20) undergoing CABG.
- Follow-up data was collected for a mean of 23 months (range 4-41 months), with 98% completeness.
- Life-table analysis was used to assess survival rates.
Main Results:
- 90% of surviving patients experienced significant improvement or complete resolution of angina.
- The operative mortality rate was 9.7% (6 deaths).
- Two-year survival rate was 85%, comparable to patients with preserved ventricular function.
Conclusions:
- Coronary revascularization via CABG is a viable and effective treatment for patients with severe angina and impaired left ventricular function.
- Impaired ventricular function should not be considered a major contraindication for bypass grafting in current surgical practice.
Abstract:
To assess the influence of coronary revascularization on the long-term survival of patients with debilitating angina and significant impairment of left ventricular function, analysis was done of 62 consecutive patients with severe angina and hypokinetic left ventricles (LVED larger than or equal to 20) undergoing coronary bypass at N.Y.U. Medical Center between January, 1971 and May 1974. Follow-up was 98% complete, range 4 to 41 months with a mean of 23 months. Multiple bypasses were done in 94% of the group; a left-ventricular scar was excised in 16%. There were six operative deaths (mortality 9.7%) and three late deaths, all within eight months after operation. Angina was either absent or substantially improved in 90% of surviving patients. Life-table analysis shows a two-year survival of 85%, very similar to the survival rate for patients with good ventricular function. Hence, with current techniques impaired ventricular function is not a major contraindication to bypass grafting.
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