Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The "Will Rogers effect" on stage grading.

T Testa1, M A Nahum, E Spinelli

  • 1Department of General and Thoracic Surgery, University of Genoa, Italy.

Annali Italiani Di Chirurgia
|May 11, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of clinical tools to estimate the breathing effort during high-flow oxygen therapy: A multicenter cohort study.

Pulmonology·2024
Same author

Body weight variation is not an independent factor in the determination of functional hypothalamic amenorrhea in anorexia nervosa.

Journal of endocrinological investigation·2023
Same author

COVID-19 lockdown and the rate of central precocious puberty.

Journal of endocrinological investigation·2023
Same author

Stochastic epigenetic mutations as possible explanation for phenotypical discordance among twins with congenital hypothyroidism.

Journal of endocrinological investigation·2022
Same author

A systematic review on drugs for synaptic plasticity in the treatment of dementia.

Ageing research reviews·2022
Same author

Development and validation of circulating tumour cell enumeration (Epic Sciences) as a prognostic biomarker in men with metastatic castration-resistant prostate cancer.

European journal of cancer (Oxford, England : 1990)·2021
Same journal

Comparison of Small-Incision Tension-Free Mesh Repair With Scrotal Drainage and Laparoscopic Transabdominal Preperitoneal Repair for Inguinal Hernia: A Retrospective Cohort Study.

Annali italiani di chirurgia·2026
Same journal

Phyllodes Tumors: From National Guidelines to European Evidence and Collaboration.

Annali italiani di chirurgia·2026
Same journal

Anorectal Melanoma Management Evolution: A Narrative Review.

Annali italiani di chirurgia·2026
Same journal

Correlation and Responsiveness of Objective and Subjective Measures in Evaluating Periorbital Swelling After Upper Blepharoplasty: A Retrospective Study Using 3D Stereophotography and Visual Analogue Scale.

Annali italiani di chirurgia·2026
Same journal

Colonic Continuity After Splenic Flexure Resection: Does the Orientation of the Anastomosis Matter? A Retrospective Cohort Study.

Annali italiani di chirurgia·2026
Same journal

Aortic Repair in Landing Zone 2: From Chimney Technique to Branched Graft.

Annali italiani di chirurgia·2026
See all related articles

The Will Rogers phenomenon can distort clinical research survival statistics, leading to misinterpretations. This phenomenon, influenced by diagnostic advancements and varied patient populations, impacts cancer staging and trial validity.

Area of Science:

  • Oncology
  • Clinical Research Methodology
  • Biostatistics

Background:

  • The Will Rogers phenomenon describes the apparent improvement in survival rates for a specific stage of cancer due to stage migration.
  • Stage migration occurs when advancements in diagnostic imaging and staging procedures reclassify patients into different stages.
  • This phenomenon can complicate the interpretation of survival statistics in clinical research and cancer registries.

Purpose of the Study:

  • To highlight the impact of the Will Rogers phenomenon on survival statistics in clinical research.
  • To explain how stage migration, driven by diagnostic and procedural advancements, affects actuarial survival.
  • To discuss the limitations imposed by the TNM System when survival data are inhomogeneous and how it affects randomized trials.

Main Methods:

Related Experiment Videos

  • Review of existing literature on cancer staging and survival analysis.
  • Conceptual analysis of stage migration and its statistical implications.
  • Examination of the TNM System's susceptibility to the Will Rogers phenomenon.

Main Results:

  • The Will Rogers phenomenon can lead to a misreading of survival statistics, suggesting improvements that are not real.
  • Actuarial survival in each stage may appear to improve due to patients being re-staged.
  • The TNM System is compromised when survival rates are derived from diverse geographical locations, time periods, and treatment protocols.

Conclusions:

  • The Will Rogers phenomenon poses a significant challenge to the accuracy of survival statistics in clinical research.
  • Careful consideration of stage migration is essential when interpreting cancer survival data and designing clinical trials.
  • Standardization of staging criteria and data collection across different populations and eras is crucial for reliable research outcomes.