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T cell-mediated paraneoplastic ganglionitis--an autopsy case
M Drlicek1, A Bodenteich, U Setinek
1Ludwig Boltzmann Institut für Neuroonkologie, Linz, Austria. marcus.drlicek@wj.lkh.ooe.gv.at
Acta Neuropathologica
|May 11, 2000
Abstract:
A 57-year-old woman presented with subacute sensory, ataxic neuronopathy. Clinical investigation revealed a right-sided non-small-cell lung cancer. Serum investigation for specific antineuronal antibodies was negative. Histology showed T lymphocytic infiltrates in dorsal root ganglia. The observed histological pattern is similar to that described in antibody-positive cases. Thus, these findings suggest similar pathways in specific antineuronal antibody-negative and -positive cases of paraneoplastic subacute sensory neuronopathy.