Related Experiment Videos
Phosphorothioate oligodeoxynucleotides: what is their origin and what is unique about them?
1Max-Planck-Institut für experimentelle Medizin, Göttingen, Germany.
Antisense & Nucleic Acid Drug Development
|May 11, 2000
Abstract:
The development of nucleoside phosphorothioates is described in its historical context. Examples of the interaction of phosphorothioate groups, present either in oligodeoxynucleotides or in DNA, with nucleases are presented. The structural features responsible for the resistance of the phosphorothioates toward degradation by nucleases are discussed, as are the possible reasons for the high-affinity interaction of phosphorothioate oligodeoxynucleotides with certain proteins.