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Related Experiment Videos

Effect of clomipramine on monoamine metabolites in the cerebrospinal fluid of behaviorally normal dogs.

C J Hewson1, U A Luescher, J M Parent

  • 1Department of Animal and Poultry Science, University of Guelph, Ontario. chewson@wenderton.demon.co.uk

Canadian Journal of Veterinary Research = Revue Canadienne De Recherche Veterinaire
|May 11, 2000
PubMed
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Clomipramine, an effective canine compulsive disorder treatment, did not alter monoamine metabolite levels in dog cerebrospinal fluid. Further research with localized sampling is needed to understand canine CD neurobiology.

Area of Science:

  • Veterinary Neurology
  • Behavioral Pharmacology
  • Neurochemistry

Background:

  • Canine compulsive disorder (canine CD) involves abnormal conflict behaviors with unknown pathophysiology.
  • Clomipramine is an effective treatment, suggesting a neurochemical basis for canine CD.
  • Understanding clomipramine's neurochemical effects could elucidate canine CD mechanisms.

Purpose of the Study:

  • To assess clomipramine's effect on central monoamine turnover in dogs.
  • To measure serotonin, dopamine, and norepinephrine metabolite concentrations in cerebrospinal fluid (CSF).
  • To investigate the neurobiological underpinnings of canine CD.

Main Methods:

  • A randomized, placebo-controlled, AB-BA crossover study in 6 healthy dogs.
  • Administration of clomipramine (3 mg/kg, q24h, PO) or placebo.

Related Experiment Videos

  • Cisternal CSF collection at 1, 2, 4, and 6 weeks for metabolite analysis.

    • Main Results:

    • Clomipramine treatment showed no detectable effect on CSF monoamine metabolite concentrations.
    • Results contrast with human studies using lumbar CSF, highlighting potential methodological differences.
    • The study is the first of its kind in dogs investigating clomipramine's central neurochemical effects.

    Conclusions:

    • Current methods may not accurately reflect clomipramine's central neurochemical effects in dogs.
    • Localized sampling techniques like microdialysis may be necessary for future canine CD neurobiological studies.
    • Preliminary data underscore the need for further neurobiological research into canine CD.