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Benzodiazepine receptor binding in Huntington's disease: [11C]flumazenil uptake measured using positron emission
G Künig1, K L Leenders, R Sanchez-Pernaute
1PSI, Paul Scherrer Institut, PET Program, Villigen, Switzerland.
Annals of Neurology
|May 11, 2000
Abstract:
We used positron emission tomography and [11C]flumazenil to analyze the benzodiazepine receptor binding in symptomatic and asymptomatic carriers of the Huntington's disease gene. We found an inverse relationship between [11C]flumazenil and [11C]raclopride binding in the putamen of symptomatic patients, and interpret this result as GABA receptor upregulation.