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Related Experiment Videos

Reference frames for spinal proprioception: limb endpoint based or joint-level based?

G Bosco1, R E Poppele, J Eian

  • 1Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA.

Journal of Neurophysiology
|May 11, 2000
PubMed
Summary
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Sensorimotor neurons in the CNS often encode limb movement globally. This study found that dorsal spinocerebellar tract (DSCT) neurons primarily represent foot position, not individual joint angles, in anesthetized cats.

Area of Science:

  • Neuroscience
  • Motor Control
  • Proprioception

Background:

  • Sensorimotor neurons in the central nervous system (CNS) frequently encode global limb parameters for movement and posture.
  • Previous research suggested spinocerebellar neurons might use a limb-based reference frame for proprioceptive information, but distinguishing this from joint-based encoding was challenging due to coupled joint angles.

Purpose of the Study:

  • To investigate whether dorsal spinocerebellar tract (DSCT) neurons represent limb proprioception in a limb-based or joint-based reference frame.
  • To decouple foot position from limb geometry using mechanical constraints on hindlimb joints in anesthetized cats.

Main Methods:

  • Applied rigid and elastic mechanical constraints to hindlimb joints (knee and ankle) in anesthetized cats to alter limb geometry.

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  • Analyzed joint-angle covariance to quantify the effect of constraints on limb geometry.
  • Used multivariate regression models to assess the relationship between neuronal activity of DSCT neurons and limb parameters (limb axis length, orientation, and individual joint angles).

    • Main Results:

    • 53% of DSCT neurons (37/70) maintained spatial tuning unaffected by joint constraints, indicating independent foot position signaling.
    • 14% of DSCT neurons (10/70) represented specific joint angles.
    • 47% of DSCT neurons (33/70) consistently represented foot position in limb axis coordinates, while 39% (27/70) were significantly affected by limb geometry changes.

    Conclusions:

    • A significant portion of DSCT neurons consistently encode foot position in a limb-based reference frame, independent of specific joint configurations.
    • These findings support the hypothesis that the spinocerebellar pathway contributes to limb-based proprioceptive representations in the CNS.