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Updated: Aug 11, 2026

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
Published on: February 17, 2011
Clinical management of BRCA1- and BRCA2-associated breast cancer
1Department of Surgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia, USA. skarp@hsc.vcu.edu
Abstract:
The recent discovery of the breast cancer-associated genes BRCA1 and BRCA2 has changed the clinical care provided to women at high risk of breast cancer. We will review what is currently known about the clinical management of patients who bear (or are suspected of bearing) mutations in either of these two genes. The issues related to establishing a diagnosis of inherited breast cancer, deciding which women are candidates for testing, the limitations of testing, and the predictive power of these tests are addressed. The prognostic features of cancers associated with a BRCA1 and BRCA2 mutation are reviewed. Further, guidelines for prophylaxis of women with a BRCA1 or BRCA2 mutation are given and recommendations are made for the care of mutation carriers with cancer.
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