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Updated: Jul 18, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA
Published on: April 26, 2013
Review: nuclear structure and DNA replication
1National Institute of Child Health and Human Development, Building 6, Room 416, Bethesda, Maryland, 20892-2753, USA.
Abstract:
DNA replication is a highly conserved process among eukaryotes where it occurs within a unique organelle-the nucleus. The importance of this structure is indicated by the fact that assembly of prereplication complexes on cellular chromatin is delayed until mitosis is completed and a nuclear structure has formed. Although nuclear structure is dispensable for DNA replication in vitro, it does appear to play a role in vivo by regulating the concentration of proteins required to initiate DNA replication, by facilitating the assembly or activity of DNA replication forks, and by determining where in the genome initiation of DNA replication occurs.
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