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[Oligo(2'-O-tetrahydropyranylribonucleotides): hybridization properties and nuclease resistance]
M A Kuznetsova1, D V Pyshnyĭ, M N Repkova
1Novosibirsk Institute of Bioorganic Chemistry, Siberian Division, Russian Academy of Sciences, Russia.
Bioorganicheskaia Khimiia
|May 12, 2000
Abstract:
Oligo(2'-tetrahydropyranylribonucleotides) and their analogues containing a 3'-3'-internucleotide bond at the 3'-terminus are nuclease-resistant and possess rather high affinity toward RNA, the main target in the antisense approach.