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[Serum concentration of insulin-like growth factor-I in cord blood]
Objective:
To evaluate the role of insulin-like growth factor-I (IGF-I) in fetal growth and placental growth.
Methods:
Cord blood IGF-I was determined by radioimmunoassay (RIA) after serum samples were extracted with acid-ethanol. Linear correlation between variables was tested by calculating pearson's correlation coefficient. student's test was used to compare mean values between groups.
Results:
In 102 tested samples, the concentration of cord blood serum IGF-I was correlated with the gestational age, the birth weight of neonates and placental weight (r = 0.32, P < 0.001, r = 0.68, P < 0.001, r = 0.75, P < 0.001). The mean serum level of IGF-I in the small-for-gestational-age (SGA) neonates was significantly lower than that in average-for gestational-age (AGA) (t = 4.77, P < 0.001), But the serum concentration of IGF-I in the Large-for-gestational-aga (LGA) neonates was significantly higher than that of AGA neonates (t = 7.97, P < 0.001).
Conclusion:
Those results suggested that IGF-I is an important regulator for fetal and placental growth and development. It has the key role for macrosomia and IUGR forming.