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[Ovarian follicular maldevelopment in infertile women]
Objective:
To study the manifestation and outcome of ovarian follicular maldevelopment (FM) in infertile women.
Methods:
Among 296 infertile women, 80 cases with FM were taken as study group and 20 with normal ovulation as control. Serial B-ultrasonography, cervical mucus scoring, serum estradiol (E2) assay and laparoscopy, endometrium histology were monitored in both groups.
Results:
The incidence of FM in infertile women was 27.0%, B-ultrasonography showed many small and obscure outlined follicles in the ovarian. The maximum and mean cervical mucus socres in FM group were < 9 and 7.3 +/- 1.8, significantly lower than those in control (> 10, 13.2 +/- 1.8) (P < 0.01). So were the midcycle serum E2 levels (300 +/- 100 pmol/L vs 900 +/- 400 pmol/L, P < 0.001). No stigma was found in two-third of FM patients and no corpus luteum in about one-third. Proliferative endometrium was shown in 34.0% of the FM group.
Conclusion:
(1) FM with an incidence of 27.0% might be an important cause of infertility. (2) FM results finally in follicular atresia or multiple immature luteinized follicles.