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Related Experiment Videos

Manometric and hormonal changes after distal partial gastrectomy.

Y Yamashita1, H Inoue, K Ohta

  • 1Department of Surgical Oncology, Research Institute for Radiation Biology & Medicine, Hiroshima University, Japan.

Alimentary Pharmacology & Therapeutics
|May 12, 2000
PubMed
Summary
This summary is machine-generated.

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Distal partial gastrectomy alters esophageal motility and hormone levels, increasing regurgitation risk. These changes, including reduced lower esophageal sphincter pressure, may worsen reflux esophagitis after surgery.

Area of Science:

  • Gastroenterology
  • Surgical Oncology
  • Esophageal Physiology

Background:

  • Duodenal mechanisms contributing to alkaline esophagitis can promote esophageal carcinogenesis.
  • Distal partial gastrectomy is associated with regurgitation, a potential complication requiring mechanistic investigation.

Purpose of the Study:

  • To elucidate the mechanisms underlying regurgitation following distal partial gastrectomy.
  • To assess the impact of gastrectomy on esophageal manometry and gastrointestinal hormone profiles.

Main Methods:

  • Esophageal manometry performed on 16 patients pre- and post-distal partial gastrectomy with Bilroth reconstruction.
  • Radioimmunoassay measurement of serum gastrointestinal hormones in 10 gastrectomy patients and 9 healthy volunteers.

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Main Results:

  • Post-surgery, lower esophageal sphincter pressure decreased, while peristaltic wave amplitude and duration increased, and velocity decreased.
  • Gastrin and pancreatic polypeptide were abolished postprandially; cholecystokinin and neurotensin levels significantly increased.
  • Manometric changes were deemed disadvantageous for preventing regurgitation.

Conclusions:

  • Hormonal alterations post-gastrectomy likely suppress lower esophageal sphincter function.
  • Combined manometric and hormonal changes may exacerbate reflux esophagitis after distal partial gastrectomy.