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Related Experiment Videos

Decrease in thalamic volumes of pediatric patients with obsessive-compulsive disorder who are taking paroxetine.

A R Gilbert1, G J Moore, M S Keshavan

  • 1Department of Psychiatry, Wayne State University School of Medicine, Detroit, Mich, USA.

Archives of General Psychiatry
|May 12, 2000
PubMed
Summary

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Pediatric obsessive-compulsive disorder (OCD) is linked to larger thalamic volumes, which decrease with paroxetine treatment, correlating with symptom improvement. This suggests thalamic changes are associated with treatment response in childhood OCD.

Area of Science:

  • Neuroscience
  • Child Psychiatry
  • Radiology

Background:

  • Thalamic dysfunction is associated with obsessive-compulsive disorder (OCD).
  • Pediatric OCD onset is common, yet neuroanatomical changes in the thalamus near illness onset and during treatment remain understudied.

Purpose of the Study:

  • To investigate thalamic volume changes in children with OCD before and after treatment.
  • To explore the relationship between thalamic volume and OCD symptom severity.

Main Methods:

  • Volumetric magnetic resonance imaging (MRI) was used in 21 drug-naive children with OCD and 21 controls.
  • 10 patients with OCD underwent MRI after 12 weeks of paroxetine monotherapy.

Main Results:

  • Treatment-naive pediatric OCD patients showed significantly greater thalamic volumes than controls.

Related Experiment Videos

  • Thalamic volumes decreased significantly after paroxetine treatment, reaching control levels.
  • Reduced thalamic volume correlated with decreased OCD symptom severity.

    • Conclusions:

    • This study provides evidence of thalamic abnormalities in pediatric OCD.
    • Paroxetine treatment may be associated with a reduction in thalamic volume in children with OCD.
    • Observed volume reductions might reflect general treatment effects or spontaneous symptom improvement.