Jove
Visualize
Contact Us

Related Experiment Videos

Stimulus novelty differentially affects attentional allocation in PTSD.

M Kimble1, D Kaloupek, M Kaufman

  • 1VA Boston Healthcare System/Behavioral Science Division/National Center for PTSD, Boston University School of Medicine, Boston, Massachusetts, USA.

Biological Psychiatry
|May 16, 2000
PubMed
Summary

Posttraumatic stress disorder (PTSD) in combat veterans is linked to altered brain responses. Veterans with PTSD showed heightened P300 brainwave responses to novel, distracting sounds, suggesting an orientation bias.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Introduction and validation of the open symptom framework: a public domain modular framework for patient-reported measurement of symptoms related to cancer and its treatment.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2024
Same author

Introduction and validation of the open symptom framework: a public domain modular framework for patient-reported measurement of symptoms related to cancer and its treatment.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2024
Same author

medna-metadata: an open-source data management system for tracking environmental DNA samples and metadata.

Bioinformatics (Oxford, England)·2022
Same author

Taurine, an osteocyte metabolite, protects against oxidative stress-induced cell death and decreases inhibitors of the Wnt/β-catenin signaling pathway.

Bone·2020
Same author

Use of a non-ICU specialty ward for immediate post-operative management of head and neck free flaps; a randomized controlled trial.

Oral oncology·2019
Same author

Predictive cytokine biomarkers of clinical response to glatiramer acetate therapy in multiple sclerosis.

Journal of neuroimmunology·2016
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Neuroscience
  • Psychology
  • Trauma Studies

Background:

  • Investigated attentional allocation in Vietnam combat veterans.
  • Compared 25 veterans with PTSD to 14 without PTSD.
  • Assessed P300 amplitudes and latencies.

Purpose of the Study:

  • To examine how PTSD affects attentional processing in combat veterans.
  • To compare brain responses to auditory stimuli in different oddball tasks.
  • To understand information-processing biases in PTSD.

Main Methods:

  • Utilized three-tone and novelty oddball tasks.
  • Measured P300 event-related potentials.
  • Stimuli included frequent tones, target tones, and distractor tones/novel sounds.

Related Experiment Videos

Main Results:

  • PTSD group showed enhanced frontal P300 amplitudes to novel distractors.
  • No P300 amplitude differences for target tones in either task.
  • Differences observed only in the novelty oddball task.

Conclusions:

  • PTSD in combat veterans is associated with heightened orientation to novel, distracting stimuli.
  • Findings align with clinical PTSD presentation and information-processing bias theories.
  • Suggests attentional biases towards potentially threatening stimuli in PTSD.