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RANTES production and expression is reduced in relapsing-remitting multiple sclerosis patients treated with
C Iarlori1, M Reale, A Lugaresi
1Department of Oncology and Neuroscience, Neuroimmunology Unit, University 'Gabriele d'Annunzio', Via dei Vestini, 66013, Chieti, Italy.
Abstract:
RANTES (regulated upon activation, normal T-cell expressed and secreted), a CC chemokine, appears to play a role in the pathogenesis of relapsing-remitting multiple sclerosis (RR-MS), enhancing the inflammatory response within the nervous system. We have demonstrated that RANTES production is increased in RR-MS compared to controls. Interferon-beta-1b (IFN-beta-1b) treatment reduces RANTES production in sera and peripheral blood adherent mononuclear cell (PBAM) supernatants both in relapse and remission. IFN-beta-1b also reduces RANTES expression in PBAM. Our results suggest that RANTES modulation might represent one of the mechanisms of action of IFN-beta-1b in RR-MS.