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[Participation of the rat caudate nucleus in the immunostimulating effect of DAGO]
L V Devoĭno1, M A Cheĭdo, E L Al'perina
1Institute of Physiology, Siberian Branch of the Russian Acad. Med. Sci., Novosibirsk, Russia.
Abstract:
The data obtained suggest that administration of the DAGO increased the number of plaque- and rosette-forming cells after immunisation with the sheep red blood cells in the sham-operated Wistar rats. Following destruction of the caudate nucleus, the DAGO administration prevented the immune activation. Bilateral destruction of the caudate nucleus resulted in a considerable inhibition of the immune response as compared with the control rats. Thereupon the caudate nucleus seems to be involved in realisation of the DAGO-induced immune activation.