Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effect of mild hypothermia on cerebral oxygen uptake during gradual cerebral perfusion pressure decrease in piglets.

R Bauer1, H Fritz, B Walter

  • 1Traumatic Brain Injury and Perinatal Research Group, Institute for Pathophysiology, Friedrich Schiller University, Jena, Germany.

Critical Care Medicine
|May 16, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unusual cases of penile vascular tumors in dogs: report of two cases.

Veterinary research communications·2026
Same author

Nutrient additions to seagrass seed planting improve seedling emergence and growth.

Frontiers in plant science·2022
Same author

Serum anti-Müllerian hormone concentration as a diagnostic tool to identify testicular tissue in canine disorders of sexual development.

Domestic animal endocrinology·2021
Same author

Afferent vagal stimulation via gastric electrical stimulation alters sympathetic-vagal balance in domestic pigs - a pilot trial.

Journal of biological regulators and homeostatic agents·2021
Same author

Non-viral reprogramming of human nucleus pulposus cells with FOXF1 via extracellular vesicle delivery: an in vitro and in vivo study.

European cells & materials·2021
Same author

In vivo biomarkers of structural and functional brain development and aging in humans.

Neuroscience and biobehavioral reviews·2020

Mild hypothermia reduces brain energy demand and improves cerebral oxygen balance in piglets. This protective effect, even during severe blood flow reduction, suggests mechanisms beyond just lowered metabolism.

Area of Science:

  • Neuroscience
  • Physiology
  • Pediatrics

Background:

  • Reduced cerebral blood flow (CBF) poses a risk to brain function, especially in vulnerable populations.
  • Cerebral oxygen metabolism is critical for maintaining brain function during ischemic events.
  • Understanding protective strategies like hypothermia is vital for managing neonatal brain injury.

Purpose of the Study:

  • To investigate the impact of mild hypothermia on cerebral oxygen metabolism and brain function in piglets.
  • To assess the effects of hypothermia during progressively reduced cerebral perfusion pressure (CPP).

Main Methods:

  • A comparative study involving normothermic (NT) and mild hypothermic (HT) groups of 14-day-old piglets (n=7 each).
  • Gradual reduction of CPP was induced using an epidural balloon to simulate reduced blood flow.

Related Experiment Videos

  • Cerebral metabolic rate of oxygen (CMRO2) and electrocorticogram (ECoG) were monitored.

    • Main Results:

    • Mild hypothermia significantly reduced CMRO2 by 50% and altered ECoG patterns.
    • Cerebral oxygen balance remained improved in hypothermic piglets until CPP was reduced by 50%.
    • During severe CPP reduction, hypothermia offered less CMRO2 reduction but better preserved high-frequency ECoG activity.

    Conclusions:

    • Mild whole-body hypothermia enhances cerebral oxygen balance by decreasing brain energy demand in piglets.
    • Hypothermia improves brain oxygen availability during mild to moderate CPP reduction.
    • The findings suggest that hypothermia's neuroprotective mechanisms may extend beyond reduced oxidative metabolism.