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Related Experiment Videos

Tolcapone increases maximum concentration of levodopa.

T Müller1, D Woitalla, D Schulz

  • 1Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Federal Republic of Germany. thomas.mueller@ruhr-uni-bochum.de

Journal of Neural Transmission (Vienna, Austria : 1996)
|May 16, 2000
PubMed
Summary

Adding tolcapone to levodopa significantly increased levodopa

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Clinical Pharmacy

Background:

  • Previous studies on healthy volunteers showed no significant increase in levodopa's maximum concentration (Cmax) with tolcapone.
  • Tolcapone is a catechol-O-methyltransferase inhibitor used in Parkinson's disease treatment.

Purpose of the Study:

  • To compare levodopa pharmacokinetics in parkinsonian patients before and after adding tolcapone.
  • To investigate the impact of tolcapone on levodopa Cmax in patients with Parkinson's disease.

Main Methods:

  • Pharmacokinetic analysis of levodopa plasma levels.
  • Study conducted in 13 treated parkinsonian subjects under standardized conditions.
  • Comparison of levodopa Cmax before and after tolcapone administration.

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Main Results:

  • A significant increase in the maximum concentration (Cmax) of levodopa was observed after adding tolcapone.
  • This finding contrasts with previous studies conducted on healthy volunteers.

Conclusions:

  • The increased levodopa Cmax in parkinsonian patients treated with tolcapone may contribute to dyskinesia.
  • Early-onset dyskinesia during tolcapone treatment could be linked to altered levodopa pharmacokinetics.