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Kidney transplantation together with another solid organ from the same donor--a single-center progress report
R Margreiter1, W Steurer, B Spechtenhauser
1Department of Transplant Surgery, Innnsbruck University Hospital, Austria.
Clinical Nephrology
|May 16, 2000
Summary
Combined kidney transplants, including pancreas or liver, show favorable outcomes. Simultaneous pancreas-kidney transplants do not harm kidney survival, and liver-kidney transplants may offer immunoprotection for the kidney.
Area of Science:
- Nephrology
- Transplantation Surgery
- Immunology
Background:
- Combined organ transplantation is a complex procedure.
- Understanding outcomes and potential benefits is crucial for patient management.
Purpose of the Study:
- To update experience with combined renal transplantation at our center.
- To evaluate outcomes of simultaneous pancreas-kidney and liver-kidney transplants.
Main Methods:
- Retrospective analysis of 93 pancreas-kidney transplants (bladder drainage) and 40 pancreatoduodenal-renal transplants (enteric drainage).
- Analysis of 20 combined liver-kidney transplants.
- Cyclosporine A and FK-based immunosuppression were used.
Main Results:
- One-year patient, kidney, and pancreas survival rates were high for both pancreas-kidney groups.
- Liver-kidney transplants showed 5-year patient and kidney survival of 70% and liver survival of 62%.
- No renal transplant rejections were observed in liver-kidney recipients, suggesting an immunoprotective effect.
Conclusions:
- Simultaneous pancreas transplantation does not negatively impact renal transplant outcomes.
- Liver transplantation may provide an immunoprotective effect for the kidney in combined liver-kidney transplants.