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Related Experiment Videos

Topical liquiritin improves melasma.

M Amer1, M Metwalli

  • 1Department of Dermatology, Zagazig University, Egypt.

International Journal of Dermatology
|May 16, 2000
PubMed
Summary
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Liquiritin cream effectively reduced melasma pigmentation over four weeks in a clinical study. This topical treatment showed promising results for melasma management, offering a potential new therapeutic option.

Area of Science:

  • Dermatology
  • Cosmetic Science

Background:

  • Melasma is a common hyperpigmentation disorder affecting facial skin.
  • Current treatments for melasma have varying efficacy and potential side effects.

Purpose of the Study:

  • To evaluate the efficacy and safety of liquiritin cream for treating epidermal melasma.
  • To compare the effects of liquiritin cream against a vehicle control.

Main Methods:

  • A randomized, split-face study involving twenty women diagnosed with epidermal melasma.
  • Participants applied liquiritin cream to one side of the face and a vehicle cream to the other, twice daily for four weeks.
  • Melasma intensity and lesion size were assessed using a five-point scale and millimeter grid, respectively, with follow-ups for ten weeks.

Related Experiment Videos

Main Results:

  • Liquiritin cream demonstrated a reduction in melasma pigmentary intensity compared to the vehicle control.
  • Clinical evaluations at week 4 indicated a positive overall response to liquiritin treatment.
  • No significant side effects were reported during the study period.

Conclusions:

  • Liquiritin cream is a safe and effective topical treatment for epidermal melasma.
  • The study supports liquiritin's potential as a therapeutic agent for improving melasma.
  • Further research may explore long-term efficacy and optimal application protocols.