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Related Experiment Videos

The human T cell receptor alpha variable (TRAV) genes.

D Scaviner1, M P Lefranc

  • 1Laboratoire d'ImmunoGénétique Moléculaire, CNRS, Université Montpellier II, Montpellier, France.

Experimental and Clinical Immunogenetics
|May 16, 2000
PubMed
Summary
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This report details human T cell receptor alpha variable (TRAV) genes, providing comprehensive tables on their repertoire, germline organization, and nomenclature. It serves as a key resource for immunogenetics research.

Area of Science:

  • Immunogenetics
  • Molecular Biology
  • Genomics

Background:

  • The T cell receptor (TCR) is crucial for adaptive immunity.
  • Understanding the diversity of TCR genes, specifically TRAV genes, is essential for studying immune responses.
  • The IMGT database is a primary resource for immunogenetic information.

Purpose of the Study:

  • To present the eighth report in the 'IMGT Locus in Focus' series, concentrating on human TRAV genes.
  • To provide updated and organized data on human germline TRAV genes and their repertoire.
  • To facilitate consistent nomenclature and understanding of human TRAV gene organization.

Main Methods:

  • Compilation and presentation of data in four distinct tables.
  • Leveraging the IMGT (the international ImMunoGeneTics database) as the data source.

Related Experiment Videos

  • Organizing information on gene number, genomic location, alleles, and nomenclature correspondence.

    • Main Results:

    • Detailed enumeration of human germline TRAV genes located at 14q11.
    • Characterization of the potential repertoire of human TRAV genes.
    • Presentation of a comprehensive human TRAV allele table.
    • Clarification of correspondences between different human TRAV gene nomenclatures.

    Conclusions:

    • The report consolidates critical information on human TRAV genes, enhancing the utility of the IMGT database.
    • This resource aids researchers in accurately identifying and analyzing human TRAV genes.
    • Standardized nomenclature and repertoire data are vital for advancing immunogenetic studies.