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The human T cell receptor alpha joining (TRAJ) genes.
1Laboratoire d'ImmunoGénétique Moléculaire, CNRS, Université Montpellier II, Montpellier, France.
Experimental and Clinical Immunogenetics
|May 16, 2000
Summary
This report details human T cell receptor alpha joining (TRAJ) genes, providing comprehensive tables of germline genes, alleles, and their nucleotide/protein sequences. These essential resources are vital for immunogenetics research and understanding T cell receptor diversity.
Area of Science:
- Immunogenetics
- Molecular Biology
- Genomics
Background:
- The T cell receptor (TCR) is crucial for adaptive immunity.
- TCR alpha joining (TRAJ) genes are key components of the TCR alpha chain.
- Accurate characterization of TRAJ genes is fundamental for immunogenetic studies.
Purpose of the Study:
- To present a comprehensive overview of human T cell receptor alpha joining (TRAJ) genes.
- To provide updated and organized data on human TRAJ germline genes and alleles.
- To make these genetic resources readily accessible to the scientific community.
Main Methods:
- Compilation and curation of human germline TRAJ gene data.
- Detailed cataloging of known human TRAJ alleles.
- Generation of nucleotide and protein sequence displays for human TRAJ alleles.
Main Results:
- Publication of three key tables: Human germline TRAJ genes, Human TRAJ allele table, and Nucleotide and protein displays of human TRAJ alleles.
- These tables offer a consolidated view of human TRAJ genetic information.
- Data is accessible via the IMGT Marie-Paule page of the IMGT database.
Conclusions:
- The presented data serves as a valuable resource for researchers in immunogenetics and related fields.
- Understanding TRAJ gene diversity is critical for studying T cell repertoire and immune responses.
- The IMGT database continues to be an essential hub for immunogenetic information.