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Related Experiment Video

Updated: Jul 10, 2026

The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
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Transgenic mice expressing bovine GH develop arthritic disorder and self-antibodies.

S Ogueta1, I Olazabal, I Santos

  • 1Departamento de Biología Molecular, Centro de Biología Molecular-Severo Ochoa, Facultad de Ciencias (UAM-CSIC), Cantoblanco, 28049 Madrid, Spain.

The Journal of Endocrinology
|May 16, 2000
PubMed
Summary
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Transgenic mice expressing bovine growth hormone (bGH) developed joint damage resembling osteoarthritis and an associated immune disorder. These mice offer a model for studying growth hormone

Area of Science:

  • Endocrinology
  • Immunology
  • Rheumatology

Background:

  • Transgenic mice expressing bovine GH (bGH) under the PEPCK promoter were developed.
  • Movement disability was observed in 6-month-old mice.

Purpose of the Study:

  • To investigate joint pathology and immune system alterations in PEPCK-bGH transgenic mice.
  • To determine if these mice serve as a model for osteoarthritis and immune-related arthritis.

Main Methods:

  • Histological examination of knee joints (synovial and articular cartilage tissues).
  • Serological analysis for autoantibodies (anti-nuclear, anti-ssDNA, anti-dsDNA, anti-70K) and immunoglobulin typing.

Main Results:

  • Joint histology revealed loss of cartilage zonal structure, clefts, chondrocyte hypertrophy, synovial thickening, and pannus formation, indicative of osteoarthritic changes.

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  • Mice exhibited elevated levels of various autoantibodies and altered immunoglobulin profiles, suggesting an immune disorder.
  • The observed joint damage and immune dysregulation were correlated.

    • Conclusions:

    • PEPCK-bGH transgenic mice develop a form of arthritis with osteoarthritic features and an associated immune disorder.
    • These mice represent a valuable animal model for exploring the role of growth hormone in immune cells and the pathogenesis of arthritis.