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Updated: Aug 15, 2026

A Neonatal Mouse Spinal Cord Compression Injury Model
Published on: March 27, 2016
Analysis of posterior spinal wiring in a validated rabbit model
R S Jackson1, M A Asher, R G Lark
1University of Kansas Medical Center, Section of Orthopedic Surgery, Kansas City 66150-7387, USA.
Abstract:
Mamillary and spinous process base wiring did not improve L5-L6 posterolateral fusion rate, stiffness, or strength in a previously established rabbit model. Specimen radiography significantly underestimated fusion rate when compared with manual palpation (37% versus 68%). Fused specimens were significantly stiffer (67.2 N/mm versus 41.1 N/mm) and stronger (177 N versus 121 N) in tension than were nonfused specimens. Deep wound infection, detected only at the time of sacrifice, apparently was more common with internal fixation (43% versus 21%). Noninfected specimens were significantly stiffer (63.3 N/mm versus 43.0 N/mm) and stronger (176 N versus 107 N) than were infected specimens.

