Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Apoptin.

A Pietersen1, H M Noteborn

  • 1Department of Molecular Cell Biology, Leiden University Medical Center, The Netherlands.

Advances in Experimental Medicine and Biology
|May 16, 2000
PubMed
Summary
This summary is machine-generated.

Apoptin effectively induces apoptosis in tumor cells resistant to conventional therapies, offering a promising new cancer treatment with minimal side effects. This novel agent bypasses common resistance mechanisms, showing potential for improved patient outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quality assessment of pacemaker implantations in Denmark.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2002
Same author

Prolonged QTc interval predicts mortality in patients with Type 1 diabetes mellitus.

Diabetic medicine : a journal of the British Diabetic Association·2001
Same author

QTc interval length and QT dispersion as predictors of mortality in patients with non-insulin-dependent diabetes.

Scandinavian journal of clinical and laboratory investigation·2000
Same author

Tissue temperatures and lesion size during irrigated tip catheter radiofrequency ablation: an in vitro comparison of temperature-controlled irrigated tip ablation, power-controlled irrigated tip ablation, and standard temperature-controlled ablation.

Pacing and clinical electrophysiology : PACE·2000
Same author

Temperature-controlled radiofrequency ablation of cardiac tissue: an in vitro study of the impact of electrode orientation, electrode tissue contact pressure and external convective cooling.

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing·1999
Same author

Lesion dimensions during temperature-controlled radiofrequency catheter ablation of left ventricular porcine myocardium: impact of ablation site, electrode size, and convective cooling.

Circulation·1999

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Therapeutics

Background:

  • Tumor cells exhibit resistance to apoptosis, a key challenge in cancer therapy.
  • This resistance is often linked to mutations in tumor suppressors like p53 or oncogenes such as Bcl-2.
  • Existing therapies face limitations due to tumor resistance mechanisms.

Purpose of the Study:

  • To investigate Apoptin as a novel anti-cancer agent.
  • To evaluate Apoptin's efficacy in inducing apoptosis in resistant tumor cells.
  • To assess Apoptin's safety profile and potential for targeted cancer therapy.

Main Methods:

  • Apoptin's mechanism of action was studied in relation to p53, Bcl-2, and BCR-ABL.
  • Apoptosis induction was assessed in human tumorigenic and normal diploid cells.

Related Experiment Videos

  • In-vivo studies were conducted using a prototype Apoptin-based anti-tumor therapy.

    • Main Results:

    • Apoptin induces apoptosis independently of p53 and is stimulated by Bcl-2.
    • Apoptin is insensitive to BCR-ABL, overcoming specific resistance pathways.
    • Apoptin selectively targets human tumorigenic cells, sparing normal cells.
    • In-vivo studies demonstrated low acute toxicity and significant anti-tumor efficacy.

    Conclusions:

    • Apoptin represents a novel therapeutic strategy for overcoming chemo- and radio-therapy resistance in tumors.
    • Its selective action on cancer cells suggests a favorable safety profile with potentially minor side effects.
    • Apoptin shows promise as an effective and well-tolerated anti-cancer agent.