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Granulation of acetaminophen by a rotating fluidized-bed granulator
T Kawaguchi1, H Sunada, Y Yonezawa
1Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Pharmaceutical Development and Technology
|May 16, 2000
Summary
This study optimized rotating fluidized-bed granulation for acetaminophen, finding ideal parameters for strong, plastic tablets. Different drug formulations exhibited unique wetting and compression behaviors, impacting tablet quality.
Area of Science:
- Pharmaceutical Technology
- Materials Science
Background:
- Optimizing granulation is crucial for effective tablet formulation.
- Rotating fluidized-bed granulation offers potential for enhanced granule properties.
Purpose of the Study:
- To evaluate rotating fluidized-bed granulation for acetaminophen.
- To determine optimal granulation parameters for tablet quality.
- To compare granulation behavior of acetaminophen with ethenzamide and ascorbic acid.
Main Methods:
- Utilized a rotating fluidized-bed granulator.
- Varied blade rotation rate, air flow rate, and spraying pressure.
- Assessed granule binding force, tablet plasticity, wetting, and compression behaviors.
Main Results:
- Optimal parameters: 300 rpm blade rotation, 42 m3/hr air flow, 1.5 kg/cm3 spraying pressure.
- Acetaminophen, ethenzamide, and ascorbic acid showed distinct wetting and compression characteristics.
- Increased drug content generally improved tablet hardness, with exceptions.
- Observed capping in acetaminophen and sticking in ascorbic acid formulations.
Conclusions:
- Rotating fluidized-bed granulation is effective for producing acetaminophen granules with desirable tablet properties.
- Drug-specific properties significantly influence granulation and tablet performance.
- Formulation optimization is essential for mitigating issues like capping and sticking.