Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Ion channels and arrhythmias].

U Borchard1, D Hafner

  • 1Heinrich-Heine-Universität Düsseldorf, Institut für Pharmakologie, Düsseldorf.

Zeitschrift Fur Kardiologie
|May 16, 2000
PubMed
Summary

Cardiac arrhythmias stem from altered ion channel currents. Understanding disturbances in automaticity, triggered activity (early/late afterdepolarizations), and reentry mechanisms is key to developing targeted therapies for tachyarrhythmias.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Field-induced transition within the superconducting state of CeRh<sub>2</sub>As<sub>2</sub>.

Science (New York, N.Y.)·2021
Same author

Antimicrobial susceptibility of bacterial isolates from patients presenting with ear, nose and throat (ENT) infections in the German community healthcare setting.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2017
Same author

Double-blind, placebo-controlled, dose-ranging study of new recombinant hypoallergenic Bet v 1 in an environmental exposure chamber.

Allergy·2013
Same author

Comparative activity of pradofloxacin and marbofloxacin against coagulase-positive staphylococci in a pharmacokinetic-pharmacodynamic model based on canine pharmacokinetics.

Journal of veterinary pharmacology and therapeutics·2012
Same author

Global histone modification pattern predicts poor prognosis in organic hyperinsulinism.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2011
Same author

Loss of PTEN expression in neuroendocrine pancreatic tumors.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2011

Area of Science:

  • Cardiology
  • Molecular Biology
  • Electrophysiology

Background:

  • Cardiac arrhythmias are primarily caused by alterations in ionic currents across the myocardial cell membrane.
  • Three fundamental mechanisms—disturbances in automaticity, triggered activity, and reentry—initiate tachyarrhythmias.

Purpose of the Study:

  • To elucidate the roles of specific ionic currents (e.g., If, ICa-L, INa, IK) in the pathogenesis of cardiac arrhythmias.
  • To differentiate the ionic bases of early afterdepolarizations (EADs) and late afterdepolarizations (LADs) and their associated arrhythmias.
  • To analyze the distinct ionic current dependencies of reentry mechanisms and their therapeutic implications.

Main Methods:

  • Review and synthesis of existing literature on ion channel function and cardiac electrophysiology.
  • Analysis of the contribution of inward and outward currents to abnormal automaticity and triggered activity.
  • Categorization of reentry circuits based on conduction disturbances and excitable gap characteristics.

Main Results:

  • Abnormal automaticity involves currents like ICa-L, INa, and IK in working myocardium, while If, ICa-L, ICa-T, and IK-ACh,Ado affect pacemaker cells.
  • EADs are linked to inhibited IKr/IKs and increased INa/ICa-L, whereas LADs result from Ca2+ overload and the transient inward current (Iti).
  • Reentry, the most common cause, is classified into Na+/Ca2+-channel dependent (long excitable gap) and Na+-channel dependent (short excitable gap) types.

Conclusions:

  • Targeting specific ion channels (Na+, Ca2+, K+) offers distinct therapeutic strategies for interrupting reentry.
  • Understanding the ionic underpinnings of automaticity and triggered activity is crucial for managing complex arrhythmias.
  • Pharmacological modulation of ion channels provides avenues for treating conditions like torsade de pointes and digitalis-induced arrhythmias.

Related Experiment Videos