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Related Experiment Videos

[Atrial defibrillator].

W Jung1, B Lüderitz

  • 1Medizinische Universitätsklinik und Poliklinik II, Bonn.

Zeitschrift Fur Kardiologie
|May 16, 2000
PubMed
Summary
This summary is machine-generated.

The Metrix System, an implantable atrial defibrillator, effectively restores sinus rhythm in atrial fibrillation (AF) patients. This device offers a safe alternative for those unresponsive to external cardioversion, though patient comfort needs improvement.

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Area of Science:

  • Cardiology
  • Biomedical Engineering

Background:

  • Atrial fibrillation (AF) is a common arrhythmia causing significant mortality and morbidity.
  • External cardioversion is effective but requires anesthesia; internal atrial defibrillation is an alternative.
  • The Metrix System is a novel stand-alone implantable atrial defibrillator (IAD).

Purpose of the Study:

  • To evaluate the safety and efficacy of the Metrix System for treating atrial fibrillation.
  • To assess the device's performance in restoring sinus rhythm and managing AF episodes.

Main Methods:

  • The Metrix System uses internal atrial defibrillation with leads in the right atrium and coronary sinus.
  • The device allows programmable modes including automatic detection, patient activation, and bradycardia pacing.
  • A multicenter clinical trial (Phase I) involved implanting 51 Metrix systems.

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Main Results:

  • The Metrix System demonstrated excellent detection accuracy (100% specificity, 92.3% sensitivity) and R-wave synchronization.
  • The device successfully converted 96% of spontaneous AF episodes, with no proarrhythmias reported from over 3700 shocks.
  • Defibrillation thresholds and electrograms remained stable post-implantation; some patients required multiple shocks or experienced adverse events like infection or cardiac tamponade.

Conclusions:

  • The implantable atrial defibrillator (Metrix System) shows promise as a therapeutic option for specific AF patient subgroups.
  • It is effective for drug-refractory, symptomatic, long-lasting, infrequent AF episodes.
  • Further research is needed to enhance patient comfort and broaden acceptance of internal atrial defibrillation therapy.