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Updated: Jul 23, 2026

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Published on: June 7, 2012
Estrogen replacement therapy and gallbladder disease in postmenopausal women
Objective:
To examine the role of estrogen replacement therapy on the development of gallbladder disease in postmenopausal women.
Design:
Systematic review of the English literature was conducted. All studies that addressed the association between hormone replacement therapy and gallbladder disease published from 1970 to the present were reviewed.
Results:
Seven observational studies, two clinical trials, two case series, and one nonrandomized and three randomized investigations were reviewed. The results of each study were reported and analyzed.
Conclusions:
Estrogen replacement therapy in postmenopausal women increased the chances for gallstone formation.
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