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Related Experiment Videos

Intraocular involvement in multifocal fibrosclerosis.

W R Morris1, B G Haik, D Osborn

  • 1Department of Ophthalmology, University of Tennessee, Memphis 38163, USA.

Ophthalmology
|May 16, 2000
PubMed
Summary
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Multifocal fibrosclerosis can affect the choroid, presenting as masses similar to abdominal fibrosclerosis. External beam radiotherapy effectively treated these intraocular masses, leading to their disappearance.

Area of Science:

  • Ophthalmology
  • Pathology
  • Oncology

Background:

  • Multifocal fibrosclerosis is a rare systemic condition characterized by excessive fibrous tissue proliferation.
  • Intraocular involvement in multifocal fibrosclerosis is uncommon and poorly understood.
  • This case report details the clinical and histopathologic findings of choroidal involvement.

Observation:

  • A patient with multifocal fibrosclerosis developed significant choroidal masses.
  • Initial treatments with corticosteroids and methotrexate were ineffective.
  • External beam radiotherapy was administered due to persistent visual impairment and mass size.

Findings:

  • Choroidal biopsy revealed fibrosclerosis consistent with systemic disease.
  • Histopathologic examination of enucleated eyes confirmed fibrosclerotic changes in the choroid.

Related Experiment Videos

  • External beam radiotherapy resulted in complete resolution of the choroidal masses.

    • Implications:

    • Multifocal fibrosclerosis can manifest in the choroid with characteristic histopathologic features.
    • External beam radiotherapy shows promise as an effective treatment for intraocular multifocal fibrosclerosis.
    • This finding expands the understanding of systemic fibrosclerosis manifestations and treatment options.