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Intraocular involvement in multifocal fibrosclerosis.
W R Morris1, B G Haik, D Osborn
1Department of Ophthalmology, University of Tennessee, Memphis 38163, USA.
Ophthalmology
|May 16, 2000
Summary
Multifocal fibrosclerosis can affect the choroid, presenting as masses similar to abdominal fibrosclerosis. External beam radiotherapy effectively treated these intraocular masses, leading to their disappearance.
Area of Science:
- Ophthalmology
- Pathology
- Oncology
Background:
- Multifocal fibrosclerosis is a rare systemic condition characterized by excessive fibrous tissue proliferation.
- Intraocular involvement in multifocal fibrosclerosis is uncommon and poorly understood.
- This case report details the clinical and histopathologic findings of choroidal involvement.
Observation:
- A patient with multifocal fibrosclerosis developed significant choroidal masses.
- Initial treatments with corticosteroids and methotrexate were ineffective.
- External beam radiotherapy was administered due to persistent visual impairment and mass size.
Findings:
- Choroidal biopsy revealed fibrosclerosis consistent with systemic disease.
- Histopathologic examination of enucleated eyes confirmed fibrosclerotic changes in the choroid.
- External beam radiotherapy resulted in complete resolution of the choroidal masses.
Implications:
- Multifocal fibrosclerosis can manifest in the choroid with characteristic histopathologic features.
- External beam radiotherapy shows promise as an effective treatment for intraocular multifocal fibrosclerosis.
- This finding expands the understanding of systemic fibrosclerosis manifestations and treatment options.