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FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
Precise localization by microdissection/reverse ISH and FISH of the t(15;17)(q24;q21.1) chromosomal breakpoints
A D Stock1, T R Dennis, P A Spallone
1Department of Pathology, University of Nevada School of Medicine, Reno, NV 89502, USA.
Cancer Genetics and Cytogenetics
|May 17, 2000
Abstract:
The acute promyelocytic leukemia (APL M3)-associated translocation (15;17) has been described as having breakpoints variably located between 15q22 and 15q26, and 17q11 and 17q25. Most of the recent studies using DNA probes (fluorescence in situ hybridization [FISH]) for analysis have indicated the chromosome 15 breakpoint to be in 15q22. We have utilized a combination of G-banding, FISH, and chromosome microdissection/reverse ISH to precisely map the breakpoint to t(15;17)(q24;q21.1).
