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A novel translocation (17;19)(p13;p13) in a patient with acute myelomonocytic leukemia
R Brückner1, K Jentsch-Ullrich, A Franke
1Department of Human Genetics, University Hospital, Otto-von-Guericke University, Magdeburg, Germany.
Cancer Genetics and Cytogenetics
|May 17, 2000
Abstract:
We report on a patient with acute myeloid leukemia (AML M4) and a so far unrecorded translocation (17;19). The leukemia transformed from a myeloproliferative disorder (MPD) and showed a progressive fatal course. Following transformation, all leukemic cells showed an apparently balanced translocation (17;19)(p13;p13). The breakpoint regions harbor genes such as TP53 (17p13) and E2A, ENL, or LYL1 (19p13), which could be relevant in leukemogenesis. We suspect that the translocation (17;19)(p13;p13) may be a prognostic factor for transformation from chronic MPD to acute leukemia.